Poster Session C
Hematologic- and oncologic-associated rheumatic syndromes
Jose A. Gomez-Puerta, MD,PhD,MPH
Hospital Clínic
Barcelona, Spain
No financial relationships with ineligible companies to disclose
Cases treated with CAR-T cells from January 2020 to May 2024 at a single center were analyzed. Patients treated with anti-CD19 CAR-T therapy (ARI-0001, (A3B1)4-1BB/CD3ζ ) and anti–BCMA CAR-T (ARI0002h) were included. All patients were treated for hematological malignancies. None of the patients had an underlying systemic autoimmune disease before CAR-T cell therapy.
Results:
During the study period, 310 patients were treated with CAR-T cell therapy, including 180 patients with CD19 and 124 with BCMA. Only 6 patients (1.9%) had rheumatologic complications (4 males). The mean age at the time of the rheumatic manifestation was 47.3 years (range 24-59 years), and the mean time to onset was 5.5 weeks (range 2-11 weeks). The underlying diagnoses for CAR-T cell therapy were acute B lymphoblastic leukemia (3), chronic lymphocytic leukemia (1), follicular lymphoma (1), and IgD-Kappa IIb multiple myeloma (1).
The main rheumatic syndromes included inflammatory arthritis, with two cases with RA-like with biopsy-proven nodulosis (2), and one case of palindromic rheumatism. Other diagnoses included ankle osteonecrosis with periarthritis, severe myositis with necrotizing fasciitis, and one severe inflammatory toe soft tissue reaction (pseudo-podagra). The main clinical characteristics and follow-up are summarized in the table and two cases are schematized in Figure 1. Systemic and localized reactions were observed during the first weeks (mean 3.0 weeks), and inflammatory arthritis appeared after a mean time of 2 months.
Five patients had CRS (all mild), treated with tocilizumab in 5 cases and anakinra in one. Another patient had a graft-versus-host disease (GVHD)-like reaction, and none had ICANS.
Conclusion: Rheumatological complications related to CAR-T therapy are infrequent (< 2%) and usually manifest as early inflammatory complications (within the first month) or later as inflammatory arthritis (after the second month). Given the increased use of this therapy, rheumatologists need to be aware of these previously unknown complications.
Clinical characteristics and outcomes of patients with Rheumatic complications of CAR-T Cell therapy
Clinical aspects, X-rays, and MRI for 2 representative cases
J. Gomez-Puerta: AstraZeneca, 6, Boehringer-Ingelheim, 6, Eli Lilly, 6, GlaxoSmithKlein(GSK), 6, Janssen, 6, Otsuka, 6; A. Monegal: None; A. Ponce: None; P. Peris: Amgen, 6; N. Martínez: None; V. Ortiz-Maldonado: None; A. Triguero: None; C. Fernández de larrea: None; J. Delgado: None; R. Sanmartí Sala: None; M. Juan: None.