0722: Factors Associated with Relapses and Performance of the French Vasculitis Study Group Relapse Score in a Cohort of Mexican Patients with ANCA-Associated Vasculitis
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Mexico City, Federal District, Mexico
No financial relationships with ineligible companies to disclose
Andrea Hinojosa-Azaola1, Marlon Sandino-Bermúdez2, Ana Sarahí Mulia-Soto3, Juan M. Mejía-Vilet4 and Eduardo Martin Nares5, 1Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Mexico, 2Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Distrito Federal, Mexico, 3Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Ciudad de México, Mexico, 4Department of Nephrology and Mineral Metabolism, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico, Mexico City, Mexico, 5Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico Background/Purpose: Anti-neutrophil cytoplasm antibody-associated vasculitis (AAV) encompass a group of systemic inflammatory diseases with multi-organ involvement. Relapses occur in 14-44% of patients within 18-36 months of follow-up and are associated with organ damage and increased mortality. The French Vasculitis Study Group Relapse Score (FRS) was recently proposed as a model to predict the risk of relapse in AAV. It includes the parameters of PR3-ANCA positivity, glomerular filtration rate (GFR) ³ 30 mL/min/1.73 m², and age ≤ 75 years at diagnosis, with a score ranging from 0 to 3 points. The study aim was to assess the risk factors associated with relapse and the performance of the FRS in a Mexican cohort of AAV patients. Methods: This was a retrospective cohort study including patients with AAV (granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA)) who were followed for at least 12 months at a referral center in Mexico City until the first relapse, death, or last follow-up visit. Variables included demographic, clinical, laboratory, and treatment data. Statistical analysis included descriptive statistics, univariable (Student’s t test, Chi-square test, Fisher’s exact test, or Mann-Whitey U test) and multivariable (logistic regression) analyses, Kaplan-Meier survival curves, and log-rank test. Results: One-hundred patients were included, 42 (42%) men and 58 (58%) women, with a median age at diagnosis of 49 years (IQR 34-58 years). Eighty (80%) had a diagnosis of GPA and 20 (20%) had MPA. At the time of AAV diagnosis, the median BVAS/GPA score was 6 points (IQR 4-10). Over a median follow-up period of 25 months (IQR 12-54 months) from AAV diagnosis, 67 patients (67%) experienced a relapse, whereas 33 (33%) remained relapse-free. Seven patients (7%) died over a median follow-up time of 49 months (IQR 21-106 months). Table 1 summarizes the characteristics of patients with and without relapses. The variables at diagnosis independently associated with relapses were: age (OR 1.05, 95% CI 1.01-1.08, p=0.14), PR3-ANCA positivity (OR 3.22, 95%CI 1.14-9.11, p=0.027), and serum creatinine (OR 1.19, 95% CI 1.02-1.38, p=0.03). The FRS was independently associated with relapses (OR 2.78, 95% CI 1.47-5.26, p=0.002), whereas maintenance treatment with rituximab was a protective factor (OR 0.14, 95% CI 0.03-0.56, p=0.005). Of the relapses, 34 (51%) were major and 34 (51%) were minor. The most frequent manifestations during relapses were renal, ocular, and pulmonary. The FRS distribution was: 0 points (n=2), 1 point (n=11), 2 points (n=40), and 3 points (n=47), with discrimination between each score excluding 2 patients with a FRS=0 (log-rank p=0.001). The median relapse-free survival was: 179, 57, and 28 months for scores of 1, 2, and 3 points, respectively. Figure 1 displays the relapse-free survival according to the FRS, whereas Table 2 shows the 2-, 3-, and 5-year relapse risk according to the FRS. Conclusion: In this cohort, relapses were frequent. Nearly half of the patients had a FRS of 3 points at diagnosis. Risk factors associated with relapse included the individual components of the FRS, and the 5-year relapse risk was 40% for a FRS of 1, %, 41% for a FRS of 2, and 66% for a FRS of 3.
Table 1. Characteristics of the patients with and without relapses (univariable analysis)
Figure 1. Kaplan-Meier curve of the relapse-free survival in the whole cohort according to the FRS
Table 2. 2-, 3-, and 5-year relapse risk according to the FRS
A. Hinojosa-Azaola: None; M. Sandino-Bermúdez: None; A. Mulia-Soto: None; J. Mejía-Vilet: AstraZeneca, 1, 6, Boehringer-Ingelheim, 6, GlaxoSmithKlein(GSK), 6, Roche, 6; E. Martin Nares: None.