Metabolic bone disease
Laura Calvi, MD
University of Rochester
Rochester, New York, United States
Disclosure(s): No financial relationships with ineligible companies to disclose
Gabriel Mbalaviele, PhD
Washington University School of Medicine in St. Louis
St. Louis, Missouri, United States
Disclosure(s): Aclaris Therapeutics, Inc: Consultant (Ongoing), Stock options or bond holdings in a for-profit corporation or self-directed pension plan (Ongoing)
Jae-Hyuck Shim, PhD (he/him/his)
University of Massachusetts
Worcester, Massachusetts, United States
Disclosure(s): AAVAA Therapeutics: Consultant (Ongoing), Grant/Research Support (Ongoing); Samsung Biologics and Bioepis: Consultant (Ongoing)
Inflammatory bone loss is a signature feature and severe consequence of many inflammatory disorders, including inflammatory arthritis. The underlying mechanisms of bone resorption and metabolism in inflammatory settings are largely unknown. This session will highlight novel discoveries in bone metabolisms and inflammatory bone resorption. Dr. Laura Calvi will discuss the efferocytosis by bone marrow stromal cells and its effects on bone metabolism. Dr. Gabriel Mbalaviele will discuss the key role of inflammasomes in bone resorption. Dr. Jae-Hyuck Shim will discuss the molecular mechanisms of RA joint damage.
Speaker: Laura Calvi, MD – University of Rochester
Speaker: Gabriel Mbalaviele, PhD – Washington University School of Medicine in St. Louis
Speaker: Jae-Hyuck Shim, PhD (he/him/his) – University of Massachusetts