Periodic fever syndromes, autoinflammatory diseases, Still’s disease and MAS/HLH
Betsy Barnes, PhD
Feinstein Institutes for Medical Science
Manhasset, New York, United States
Disclosure information not submitted.
Susan Canny, MD, PhD
Seattle Children's Hospital/University of Washington
Seattle, Washington, United States
Disclosure(s): No financial relationships with ineligible companies to disclose
Still's disease is a severe inflammatory syndrome characterized by fever, skin rash, and arthritis affecting children and adults. Patients with Still's disease may also develop macrophage activation syndrome, a potentially fatal complication of immune dysregulation resulting in cytokine storm. Recent insights into the mechanisms behind the Still’s disease phenotype and macrophage hyperinflammation will be covered in this high-yield session, including metabolic control of T-cells by dendritic cells, TLR-driven cytopenias, and newly recognized conserved gene patterns that sub-divide patients with inflammatory disease.
Speaker: Arthur Kaser, MD – Cambridge University
Speaker: Jessica Hamerman, PhD – Benaroya Research Institute
Speaker: Grant Schulert, MD,PhD – Cincinnati Children's Hospital Medical Center