Periodic fever syndromes, autoinflammatory diseases, Still’s disease and MAS/HLH
Lori Broderick, MD, PhD
University of California San Diego
La Jolla, California, United States
Disclosure(s): Novartis: Grant/Research Support (Ongoing), Independent Contractor (Ongoing)
Marco Gattorno, MD
IRCCS Giannina Gaslini
Genoa, Genoa, Italy
Disclosure(s): Fresenius Kabi: Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Kiniksa: Consultant (Ongoing); Novartis: Grant/Research Support (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing); Sobi: Grant/Research Support (Ongoing), Speaker/Honoraria (includes speakers bureau, symposia, and expert witness) (Ongoing)
Since the initial discovery of familial Mediterranean fever, more than 50 monogenic systemic autoinflammatory syndromes (SAIDs) have been identified. However, features of autoinflammation can be seen in patients without identifiable causal genetic variants associated with known SAIDs. The term syndrome of undifferentiated recurrent fever (SURF) is used for autoinflammatory diseases characterized by self-limiting episodes of systemic inflammation without a confirmed molecular diagnosis, and also not fulfilling the criteria for periodic fever, aphthous stomatitis, pharyngitis, and adenopathy (PFAPA) syndrome. Most rheumatologists are not familiar with the diagnostic evaluation and management approaches for patients with SURF.
Speaker: Lori Broderick, MD, PhD – University of California San Diego
Speaker: Marco Gattorno, MD – IRCCS Giannina Gaslini